2000-present

2013

• Gold Spike closes in April and reopens as a restaurant & bar (no casino) 
• Bill's Gamblin' Hall closes, planned to re-open as Gansevoort in 2014 (Feb. 4)

2012

• Imperial Palace becomes The Quad (Dec.)
  
• O'Sheas closes (April 30), to be replaced by The Linq, a restaurant and entertainment district, which may house a new O'Sheas inside.
• Fitzgeralds becomes The D (Mar. 13)
• The Western closes (Jan. 16)
• Las Vegas Hilton becomes LVH (Jan. 3)

2011

• Sahara closes (May 16)

2010

• Cosmpolitan opens (Dec. 15)
• Harrah's Entertainment changes its name to Caesars Entertainment Corp. (November)
• Greek Isle becomes Clarion.  (April)

2009

• Aria opens (Dec. 16)
• Treasure Island, formerly an MGM Mirage property, is sold to Phil Ruffin for $775 million (March)

2008

• Encore opens (Dec. 22)
• Aliante Station opens (Nov. 11)
• Eastside Cannery opens (Aug. 28)
• Palazzo opens.
• Nevada Palace closes (to become Eastside Cannery). (Feb. 29)

2007

• The New Frontier closes (and is imploded in November). Plans were to build a new property called the Las Vegas Plaza (not to be confused with "The Plaza" downtown), but plans were scrapped after the economy turned sour. (3120 LVB)
• The Aladdin becomes Planet Hollywood. (April)
• Barbary Coast becomes Bill's Gamblin' Hall  (March)
  
• The Stardust is imploded (to be replaced by Echelon). (March)

2006

• The Stardust closes, and is imploded in 2007 (to be replaced by Echelon). (Nov.)
• South Coast (off-strip) changed ownership, and its name, to South Point. (Oct.)
• Gold Spike (downtown) removes its table games. RIP! (Spring)
• The Boardwalk is imploded (to be replaced by Aria / CityCenter) (May)
• San Remo (next to Strip) becomes Hooters.
• Lady Luck (downtown) closes.

2005

• Westward Ho closes (2900 LVB).
• The $2.7 billion Wynn Las Vegas opens, five years after Steve Wynn purchased the old Desert Inn. (April)
• The FTC approves the merger of MGM & Mandalay, so now one company owns a whopping nine strip casinos. (Feb.)
• The Landmark (near the Strip) is imploded (replaced by the Convention Center parking lot).
• Key Largo (near the Strip) closes.
• The Stratosphere removes the High Roller roller coaster, to make room for an outdoor observation deck.

2004

• Mandalay Bay's second tower ("THEhotel") opens.
• The Las Vegas Club changes its name to Vegas Club but they don't change the sign outside.
• Castaways (on Boulder Highway) closes.

2003

• A tiger mauls Roy Horn of Siegfried & Roy during their performance, ending their run at the Mirage which started in 1990.
• Cannery Casino (not to be confused with Eastside Cannery) opens.
• Union Plaza becomes The Plaza.

2001

• The Desert Inn is imploded (to be replaced by the Wynn).
• Wildfire Casino (North Las Vegas) replaces Ernie's Casino.

2000

• The rebuilt Aladdin opens.
• Showboat (on Boulder Highway) becomes Castaways.

1980's & 1990's

1999

• The Venetian opens.
• Paris opens.
• Mandalay Bay opens.
• The Flamingo Hilton becomes Flamingo Las Vegas.
• Saraha adds a roller coaster, Speed.

1998. Bellagio opens, on the site of the former Dunes.

1997

• New York New York opens.
• The Aladdin closes and is imploded in 1998, to be replaced by a newer version of the Aladdin.

1996

• Monte Carlo opens (replacing the Desert Rose Motel). Magician Lance Burton has been the featured performer since the opening.
• The Stratosphere opens. (formerly Vegas World, without the tower.)
• The Sands closes and is imploded (to be replaced by the Venetian in 1999).
• Hacienda closes and is imploded (to be replaced by Mandalay Bay in 1999). The casino had started in 1956.

1995. Vegas World closes (to be replaced by the Stratosphere in 1996).

1993

• Treasure Island opens.
• Luxor opens.
• MGM Grand opens (replacing Marina/MGM Marina).
• The Dunes is imploded (to be replaced by Bellagio).

1992

• Casino Royale opens in the space of the former Nob Hill Casino. It buys the Travelodge next door for hotel space.
• Holiday Casino becomes Harrah's, though the new carnival/party theme won't be installed until 1997.
• El Rancho closes (and is imploded in 2000 to make way for condos). This was not the original El Rancho, which was on the SW corner of LVB & Sahara.

1990

• Excalibur opens.
• MGM Marina closes so the MGM Grand can be constructed.
• Nob Hill closes (to reopen in 1992 as Casino Royale).
• Siegfried & Roy begin their run at the Mirage, which ends in 2003 when Roy Horn is mauled by a tiger.

1989

• The Mirage opens, launching the megaresort era.
• Marina becomes MGM Marina.

1988. Imperial Palace adds an 18-story hotel tower.

1987. Castaways closes, so the Mirage can be constructed.

1985. The original MGM Grand becomes Bally's. (The MGM Grand would open at its current location in 1990.)

1980. A fire at the original MGM Grand kills 87 people.

1980. Sundance opens downtown (current site of The D)

1980's. At some point, the Ambassador became La Mirage.

1946 - 1979

1979

• Flamingo Capri (not to be confused with the more well-known Flamingo) becomes Imperial Palace.
• Slots-a-Fun opens, the smallest casino on the Strip (and the only one without a hotel).
• Vegas World opens and runs until 1995 (to be replaced by the Stratosphere in 1996).

1978. Nob Hill Casino opens on the former site of Frank Musso's Restaurant and Joey's New Yorker Nightclub, and the future site of Casino Royale.

1975. The Marina Casino opens at what is now the MGM Grand.

1974. The Fabulous Flamingo becomes The Flamingo Hilton.

1973

• The original MGM Grand is constructed where the Bonanza Casino used to be, and where Bally's is now.
• Holiday Casino opens, later to become Harrah's.
• The Ambassador opens (later La Mirage and then Key Largo).

1971. Union Plaza opens. (July 2)

1970. The Western opens. (Closes 2012.)

1968. Circus Circus opens.

1966

• Caesars Palace opens.
• Aladdin opens (formerly King's Crown, and now Planet Hollywood).

1964. Tally-Ho becomes King's Crown, and then closes soon afterward.

1963

• Westward Ho opens and runs until 2005.
• The Sans Souci Hotel becomes Castaways Casino (not to be confused with the later Castaways on Boulder Highway), in the spot which would later become the Mirage.
• Bonanza Casino opens at what would later be Bally's.
• Tally-Ho opens on the site that would later become Planet Hollywood.

1962. Ernie's Casino opens in North Las Vegas, and lasts until 2001, when it's destroyed to make way for Wildfire Casino.

1959. The Flamingo Capri, completely unrelated to the more well-known Flamingo, opens and runs until 1979, when it becomes Imperial Palace.

1958. The Stardust opens, with the largest casino and swimming pool in Nevada, and the largest hotel in Las Vegas. It closes in 2006 and is imploded in 2007.

1957

• The Tropicana opens.
• Sans Souci Hotel (no casino) opens on the space which would later become the Mirage.

1956. Hacienda opens (and lasts until 1996 when it's imploded to make way for Mandalay Bay).

1955

• The Riviera opens, the first high-rise on the Strip.
• The Dunes opens and lasts until 1993, when it is imploded to be replaced by Bellagio.

1954. Showboat Casino opens on Boulder Highway (to become Castaways in 2000, and then close in 2004).

1953. The Desert Rose Motel opens, at what would later become Monte Carlo.

1952.

• The Sahara opens.
• The Sands opens (on what would become the Venetian in 1999).

1946. The Pink Flamingo opens, built by notorious mobster Bugsy Siegel. It is the first luxury hotel on the Strip, It would become The Fabulous Flamingo in 1947, The Flamingo Hilton in 1974, and Flamingo Las Vegas in 1999.